| abstract |
Compounds of the general formula <IMAGE> wherein R1, R2, R3, R4, R5 and R6 which may be the same or different, hydrogen, an alkyl group having 1 to 4 carbon atoms, the hydroxyl group, an alkoxy group having 1 to 4 carbon atoms, an acyloxy group 1 to 4 carbon atoms, halogen, trihalomethyl, di (alkyl with 1 to 4 carbon atoms-amino (alkoxy with 1 to 4 carbon atoms-carbonyl, nitro, cyano or acyl with 1 to 3 carbon atoms; R7 and R8, which are the same or different can, hydrogen, methyl, hydroxy, carboxy, (alkoxy having 1 to 4 carbon atoms-carbonyl, hydroxymethyl, phenyl or p-chlorophenyl; R9 and R10 are hydrogen or methyl j and k indices of 0-3, but not more than 4 in total; m and n indices from 0-3, but not more than A -CH2- or -CH2CH2; or R7 and R9 together or R8 and R10 together oxo, with the proviso that k or m are different from O; or R7 and R9 together and R8 and R10 together Oxo, with the measure be that k and m are different from O; or R11 and R12, which may be the same or different, one to four methyl substituents on the carbon atoms of a piperazine ring (A = -CH2-); R13, R14, R15 and R16, which may be the same or different, are hydrogen or methyl, or R13 and R14 together and / or R15 and R16 together oxo; and X represents an alkylene chain with 1 to 2 carbon atoms, which is optionally substituted by hydroxy, and their physiologically acceptable acid addition salts. The compounds and their salts are valuable anti-allergic and anti-inflammatory agents. |