abstract |
N-piperazinylalkanoylanilides of formulan wherein is O, 1 or2, each of Rand R, is H or alkyl, and each of R 2 , R 3 and R 4 is H, halogen, alkyl, hydroxy-alkyl, alkoxy, aralkoxy, alkylthio, aralkylthio, alkylsulphonyl, alkylsulphenyl, NO 2 , NH 2 , alkylamino, acylamino, ureido, alkylureido, alkylsulphonylamino, CF 3 , acyl, CN, COOH, alkoxycarbonyl, NH 2 CO, SO 3 H, guanidinosulphonyl, NH 2 COO, OH, acyloxy, alkylsulphonyloxy, alkylenedioxy or SO 2 NR 5 R 6 wherein each of R 5 and R 6 is H, alkyl, aryl or acyl, and their pharmaceutically acceptable acid addition salts, are antihypertensive agents. n They may be prepared by condensing 1-(2-methoxyphenyl)- -piperazine with an alkanoylanilide of formula |