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filingDate 1984-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1988-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1988-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0120289-B1
titleOfInvention Process for the preparation of chiral b-lactams
abstract 1. A process for the manufacture of chiral beta-lactams of the general formula see diagramm : EP0120289,P14,F1 wherein R**1 signifies a readily cleavable protecting group, R**2 signifies azido, phthalimido or the group ROCO-CH=C(CH3 )-NH-, R signifies lower alkyl and R**3 and R**4 each individually signify hydrogen or lower alkyl or together signify alkylene with a maximum of 6 carbon atoms, and the groups denoted by lower have a maximum of 4 carbon atoms, characterized by reacting a lactone of the general formula see diagramm : EP0120289,P14,F2 wherein R**3 and R**4 have the above significance, with an alkali metal periodate, reacting the resulting aldehyde of the general formula see diagramm : EP0120289,P14,F3 wherein R**3 and R**4 have the above significance, with an amine of the general formula H2 N-R**1 wherein R**1 has the above significance, and reacting the thus-obtained compound of the general formula see diagramm : EP0120289,P14,F4 wherein R**1, R**3 and R**4 have the above significance, in the presence of a base with a reactive derivative of a carboxylic acid of the general formula R**2-CH2 -COOH wherein R**2 has the above significance.
priorityDate 1983-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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