| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1dfd39878009ed672c93ba0247ee666 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-58 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-58 |
| filingDate |
1983-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54b00879f9f798e24d3a1f66588f983d |
| publicationDate |
1984-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0116784-A2 |
| titleOfInvention |
Atrial natriuretic factor |
| abstract |
Diuretic and natriuretic extracts, which have been characterized as peptide in nature, have been obtained by homogenization of mammalian heart atria with an aqueous solution of a lower carboxylic acid and may be prepared synthetically. After precipitation of impurities by pH adjustment, the extract may be further purified chromatographically. Extracts injected into test rats resulted in 30-40 fold increases in sodium and chloride excretions within 5 - 10 minutes of injection. Urine Volume rose 10-15 fold and potassium excretion doubled. The response was complete in 20 minutes and no similar changes in renal function were observed following injection of a similarly obtained ventricular extract. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0147193-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0166585-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0166585-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0153865-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0180615-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0193349-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0182984-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4607023-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0206769-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0206769-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0182984-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5106834-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3443257-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5118615-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0180615-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0193349-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4618600-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5212286-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0147193-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0153865-A2 |
| priorityDate |
1982-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |