| abstract |
The invention relates to lipopeptides of the formula I * = R ** = R or S *** = R wherein R 1 b and R 1 b independently of one another each have an aliphatic or aliphatic-cycloaliphatic hydrocarbon radical, optionally substituted by oxygen functions, with 7-21 C atoms, or one of the radicals R 1 a -CO and R 1 b -CO are hydrogen and the other of the radicals R 1 a -CO and R 1 b -CO is an acyl radical, in which R 1 a and R 1 b are as defined above, R 2 is an aliphatic or aliphatic -cycloaliphatic, optionally substituted by oxygen functions hydrocarbon radical with 1 - 21 C atoms, n = 0 or 1, As ° a radical of the formula -O-Kw-CO- or -NH-Kw-CO-, wherein Kw for an aliphatic hydrocarbon radical with at most 12 carbon atoms, As 1 is a D- or La-amino acid, Z 1 and Z 2 independently of one another hydroxy or the N-terminal residue of a D- or La-amino-carboxylic acid, an amino-lower alkanesulfonic acid or a peptide a maximum of 6 amino acids from the group of D- or La-amino-carbo nacids and the amino-lower alkanesulfonic acids, and Z 3 is hydrogen or -CO-Z 4 , where Z 4 is hydroxy or the N-terminal residue of a D- or La-amino acid, an amino-lower alkanesulfonic acid or a peptide with a maximum of 6 amino acids from the Group of the D- or La-amino-carboxylic acids and the amino-lower alkanesulfonic acids, mean, and the amides and esters of those compounds which have carboxyl groups.n n n The new lipopeptides have an immunostimulating effect. |