| abstract |
Topical ophthalmologically acceptable composition useful for reducing and controlling the elevated intraocular pressure associated with glaucoma which comprises an angiotensin converting enzyme (ACE) inhibitor in combination with an ophthalmologically acceptable carrier. Preferred compositions contain captopril or an ACE inhibitor of formula <CHEM> wherein A is <CHEM> R2 is alkyl, benzyl, benzylthio, benzyloxy, phenylthio or phenoxy; R1, R3, R4 and R6 are hydrogen or alkyl; R5 is hydrogen, alkyl or amino alkyl; p is o, 1 or 2; q is 0, 1 or 2, provided that the sum of p and q is 1 or 2 and that p is not 0 in formula Z; r is 1 or 2. a |