| abstract |
1-phenyl-3-azabicyclo [3.1.0] hexane-2,4-diones of the formula in which R 1 is hydrogen, R 2 is hydrogen, sulfo or acyl and R 3 is hydrogen or R, a saturated or unsaturated, aliphatic, cycloaliphatic or cycloaliphatic-aliphatic hydrocarbon radical up to and including 18, preferably up to and including 12, carbon atoms, R 2 is hydrogen, lower alkyl, Sulfo or acyl and R 3 are hydrogen or lower alkyl, and salts of these compounds have valuable pharmacological properties and are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, in particular breast cancer. |