http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0113394-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50ab873817cc87bd64c119e88066ca6f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-27 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 |
| filingDate | 1983-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91a1738b4943ad4e00a5a2797738233e |
| publicationDate | 1984-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0113394-A1 |
| titleOfInvention | Cyclopeptides for use in antibacterial therapy |
| abstract | A compound having the general formula in which Dab is diaminobutyric acid; A is either leucine, threonine, isoleucine or phenylalanine; B is either leucine or threonine; D is either D-leucine or D-phenylalanine; and C is a substituent selected from the group comprising -Dab-Thr, -Dab-Thr-Dab, -Dab, -Dab-Thr-Acyl and H, in which Thr is threonine, Acyl is a lower acyl group of 1 to 5 carbon atoms and Dab is as defined above. These compounds are useful in sensitizing Gram-negative bacteria to antibacterial agents and to the host defence mechanism complement when subjecting said Gram-negative bacteria to the action of said compounds. The invention also provides a pharmaceutical composition for use in sensitizing Gram-negative bacteria to antibacterial agents, complement or both, comprising a therapeutically effective amount of said compound in admixture with a pharmaceutically acceptable carrier. Polymyxin B nonapeptide having the formula: is produced by treating polymyxin B with ficin, papain or bromelin. |
| priorityDate | 1982-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.