| abstract |
Arylphenyl ether derivatives of the formula I <IMAGE> where R is C1-C6-alkyl; Ra and Rb independently represent hydrogen, halogen or C1-C3-alkyl; Ar is phenyl which is unsubstituted or mono- or polysubstituted by halogen, C1-C3-alkyl, C1-C3-alkoxy and / or trifluoromethyl; U and V independently of one another represent C1-C12-alkyl optionally substituted by halogen or C1-C6-alkoxy or together form one of the following alkylene bridges <IMAGE>, where R1 and R2 independently of one another represent hydrogen, C1-C12-alkyl, a or C1-C12-alkyl, phenyl which is substituted by halogen several times, phenyl which is mono- or polysubstituted by halogen and / or C1-C3-alkyl or represents the group -CH2-Z-R7, where Z is oxygen or sulfur and R7 is Hydrogen, C1-C8-alkyl, a C1-C2-alkoxy substituted C1-C8-alkyl, C3-C4-alkenyl, 2-propynyl, 3-halo-2-propynyl, phenyl, a by halogen, C1-C3- Alkyl, C1-C3-alkoxy, nitro and / or CF3 mono- or polysubstituted phenyl, benzyl or a benzyl mono- or polysubstituted by halogen, C1-C3-alkyl and / or C1-C3-alkoxy; R3, R4 and R5 independently of one another are hydrogen or C1-C4-alkyl, the total number of carbon atoms in R3, R4 and R5 not exceeding 6 and R6 is hydrogen or C1-C3-alkyl; including their acid addition salts have anxiolytic, anticonvulsant and / or antifungal properties and can be used as active pharmaceutical ingredients. The arylphenyl ether derivatives of formula I are prepared by e.g. a compound of the formula II <IMAGE> in which Y represents hydrogen or a metal cation, with a compound of the formula III <IMAGE> in which X represents a nucleofugic leaving group. |