| abstract |
A compound of the general formula:n wherein A represents an unsubstituted thiazolyl or substituted thiazolyl residue having at least one substituent which is halogen, alkyl, amino or acylamido; R' represents hydrogen or alkyl, carboxymethyl or alkoxycarbonylmethyl, R 2 represents hydrogen or methyl, hydroxymethyl, acyloxymethyl or alkylthiomethyl, or represents thiadiazolylthiomethyl optionally alkyl substituted, or represents tetrazolylthiomethyl residue optionally substituted by alkyl, alkylaminoalkyl or carboxymethyl; and R 3 represents unsubstituted allyl or substituted allyl having at least one substituent which is halogen, alkyl, cycloalkyl, haloalkyl, acyloxy alkyl, alkoxycarbonyl, phenyl or substituted phenyl, or salts thereof have excellent chemical stability and are very satisfactorily absorbed to exhibit an excellent therapeutic effect on the patients having bacterial infectious diseases when administered by a method other than injection, such as oral administration. Various methods are disclosed for the preparation and formulation of the new compounds. |