| abstract |
The carbacycline derivatives correspond to formula I in which: R1 represents the CH2OH residue or $ (1,) $ - C-OR2, R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl, $ (1,) residue $ CH2 -C-aryl or a heterocyclic residue, or R1 is the residue $ (1,) $ - C-NHR3, R3 representing an alkanoyl or alkanesulfonyl residue each containing from 1 to 10 carbon atoms or the residue R2 or R1 is the remainder $ (2,) $ in which m is 1 or 2. X is an oxygen atom or a CH2 group, A is a trans group -CH = CH- or -C = C-, W is a hydrocymethylene group free or modified in which the OH group may be in the alpha or beta position, n represents the number 1, 2 or 3, D is a straight chain alkylene group with 1 to 3 carbon atoms, E represents a bond -C = C - or a group -CR6 = CR7, R6 and R7 being different and represent a hydrogen atom or an alkyl group with 1-5 carbon atoms or a hydrogen atom or a halogen atom, preferably chlorine, R4 represents an alkyl, cycloal group kyl or an optionally substituted aryl group or a heterocyclic group, R5 represents a free or modified hydroxy group. When R2 represents a hydrogen atom, the salts of the compounds with pharmaceutically acceptable bases are also concerned. The compounds are used as hypotensive agents. |