| abstract |
16-Methylene-17-keto-steroids are transformed to the ncorresponding 16-methylene-17α-hydroxyprogesterones nwhich are intermediates useful in the production of bentamethasone, diflorasone diacetate and melengesterol acentate. 17α-Hydroxy-6, 16-dimethylene-pregn-4-ene-3, 20-ndione is simultaneously isomerized and acylated to 17α-nhydroxy-6-methyl-16-methylenepregna-4, 6-diene-3, 20-ndione 17-acetate. |