| abstract |
The present invention provides compounds of the formula:- n<CHEM>n wherein A is a lower alkylene group; R<1> is a carboxy, hydroxy, protected hydroxy, lower alkoxycarbonyl, lower alkoxycarbonylamino or lower alkanoyloxy group; R<2> is a hydrogen or halogen atom or a halo (lower) - alkyl group; R<3> is a hydrogen or halogen atom; R<4> is a hydrogen atom or a hydroxy, carboxy, lower alkoxy, lower alkanoyloxy or lower alkoxycarbonyloxy group and R<5> is a hydrogen or halogen atom or R<4> and R<5> together represent the group =CH2; F is the number of double bonds which is equal to 0 or 1 and n is an integer of 0 or 1, with the proviso that when F is 0 then n is 1 and when F is 1 then n is 0; and the pharmaceutically-acceptable salts thereof. n<??>The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Futhermore, the present invention is concerned with the use of these compounds for the treatment of diabetic cataract and/or neuropathy. |