| abstract |
The invention relates to carbacyclin derivatives of the general formula I <IMAGE> wherein R1 is OR2, where R2 is hydrogen, alkyl, cycloalkyl, aryl, -CH2 -? - aryl or a heterocyclic radical, or R1 is NHR3 with R3 in the meaning of an acid radical or the radical R2 A a -CH2-CH2-, trans -CH = CH- or -C ^ C group, W a free or functionally modified hydroxymethylene group or a free or functionally modified <IMAGE> group, the OH group can be α- or β-permanent, D the group <IMAGE> is a straight-chain saturated alkylene group with 1-5 C atoms, a branched saturated or a straight-chain or branched unsaturated alkylene group with 2-5 C atoms, which, if appropriate can be substituted by fluorine atoms, n can denote the number 1, 2 or 3, E represents a direct bond, a -C ^ C group or a - CR6 = CR7 group, where R6 is hydrogen or |