| abstract |
Compounds of the formula (I):n and pharmaceutically acceptable acid addition salts thereof, wherein,n Ar is optionally substituted phenyl or naphthyl, or pyridyl; E is 0, S or a bond; R 5 is hydrogen, and J is C 3-5 polymethylene, optionally substituted by one or two groups selected from methyl or optionally derivatised hydroxy; or Ar and R s together form a groupn where Ar 1 is optionally substituted 1,2-phenylene; Z is O or CH 2 , and m is 0 or 1, when E is O or S, or 1 when E is a bond; R 1 is hydrogen, C 1-4 alkyl or optionally substituted phenyl; C 3-8 alkanoyl, or phenyl C 2-6 alkanoyl, any phenyl moiety being optionally substituted; a group COR 2 where R 2 is C 2-3 alkoxy, phenyl C 1-4 alkoxy, the phenyl moiety being optionally substituted, or C 1-4 alkoxy C 3-4 alkoxy; or a group CXNHR 3 where X is O or S and R 3 is C 2-4 alkyl, C 2-4 alkenyl, phenyl or phenyl C 1-4 alkyl, any phenyl moiety being optionally substituted; and R 4 is hydrogen or C 1-4 alkyl, compositions containing them, and processes for their preparation. |