| abstract |
Topical antiinflammatory activity is exhibited by steroids having the formulan and the 1,2-dehydro and 15,16-dehydro derivatives thereof, whereinn R 1 is hydrogen, alkyl, carboxyl, oralkoxycarbonyl; R 2 is hydrogen, chlorine, bromine, fluorine, methyl, hydroxyl or a conventional hydrolyzable ester thereof, methoxy, or oxo (=O); R 3 is carbonyl or β-hydroxymethylene; R 4 is hydrogen or fluorine; R 5 is hydrogen, methyl of fluorine; X and Y are the same or different, and each is S, O, NH, N-CH 3 , SO or S0 2 ; and nis1,2,3,4or5. |