| abstract |
Aziridine and phenathanolamine derivatives of the formulas I and II-1 wherein R 1 and R 2 are hydrogen or lower alkyl; Z 1 is phenyl or phenyl radicals which are substituted in a certain way, Z 2 and Z 21 are phenyl or thienyl radicals which are substituted in a certain way and n 1-4 have a catabolic effect and can be used for the treatment of obesity and or diabetes. The compounds of the formula I are obtained by elimination of water from β-amino alcohols, for example those of the formula II-1, which in turn are prepared by adding amines to epoxides or by reducing corresponding iminoketones or alcohols, α-keto-β-hydroxyamines or β-ketoamines can. |