| abstract |
New compounds of general formula: $ (10,) $ where Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents an alkylene having from 1 to 10 carbon atoms approximately and B represents -NR2COR1, -NR2CONR1R3, -NR2SO2R1, -NR2SO2NR1R3, or -NR2COOR1, where R1, R2 and R3 may be the same or different and may represent hydrogen, alkyl, alkoxy alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R1 does not represent hydrogen when B represents -NR2SO2R1 or -NR2COOR1, or R1 and R3 can together form with N a heterocyclic group having from 5 to 7 members; and their pharmaceutically acceptable salts. These compounds have beta adrenergic blocking activity and are also useful in the treatment of glaucoma. |