http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0089886-B1

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filingDate 1983-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0089886-B1
titleOfInvention Process for the preparation of a free alpha-l-amino acid
abstract This invention relates to a process for the preparation of free L alpha -amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures. The process according to the present invention is characterized in that the D antipodes of an ester of said alpha -amino acid is racemized in the presence of a chemical catalyst formed by at least one aromatic aldehyde corresponding to the general formula: <IMAGE> (I) wherein: Ar represents an aromatic ring optionally containing a heteroatom, such as nitrogen, and B represents a basic function, to produce a mixture in dynamic equilibrium of the two forms D and L of said ester, the ester which is present in the L form is hydrolyzed enzymatically and irreversibly to produce the corresponding stereostable L alpha -amino acid, said stages of chemical racemization and of enzymatic hydrolysis being carried out under identical reaction conditions, and the free L alpha -amino acid is recovered.
priorityDate 1982-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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