| abstract |
The invention relates to compounds of formula 1 in which n is 0 or 1, R is hydrogen, alkyl or aralkyl, R 'is hydrogen or alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each substituted by alkyl, (C 1 -C 2 ) - in each case by alkyl, (C 1 -C 2 ) - Alkoxy or halogen substituted, aralkyl or aroylalkyl, both as defined above, substituted in the aryl radical, a mono- or bicyclic sulfur or oxygen and / or nitrogen heterocycle radical or a side chain of a naturally occurring amino acid, R 2 is hydrogen, alkyl, Alkenyl or aralkyl, Y hydrogen or hydroxy, Z hydrogen or Y and Z together oxygen and X alkyl, alkenyl, cycloalkyl, aryl, by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy mono-, di- or trisubstituted, or 3-indolyl, their physiologically acceptable salts, processes for their preparation, compositions containing them and their use as medicines and bicyclic amino acid ren as their intermediates and processes for their preparation. |