| abstract |
Pharmaceutial compositions with antiphlogistic/anti- pyretic/analgesic activities containing as active ingredient theobromine and theophylline derivatives represented by the general formula:n wherein one of A and B is -CH 3 and the other of A and B isn wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formulan wherein X 1 and X 2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; and (3) a group of the formula;n n n wherein Y 1 and Y 2 are the same or different and Y 1 and Y 2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or a carbon atom, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that (i) when A is -CH 3 , m is 2, and (ii) when A isn Z is not pyridyl and X is nitrogen. |