| abstract |
Heterocyclic compounds of the formulan wherein either X is -CR 1 R 2 and Y is -O-, -S- or-NR 3 -, wherein R 1 , R 2 and R 3 , which may be the same of different, each is hydrogen or alkyl of up to 4 carbon atoms; n or X is-O-, -S- or -NH- and Y is -CF1R 2 - wherein R 1 and R 2 have the meanings stated above; n wherein either R 4 is hydrogen, fluoro or chloro, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atom, and R 5 , R 6 and R 7 , which may be the same or different, each is hydrogen, fluoro, chloro, bromo or iodo, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, provided that R 4 , R5, R 6 and R 7 are not all hydrogen; n or R 4 is bromo and R 5 , R6 and R 7 have the meanings stated above, provided that R 5 , R 6 and R 7 are not all hydrogen; n or R 4 and R 5 together, or R 5 and R 6 together, or R 4 and R 7 together, from the-CH=CH-CH=CH-group and the othertwo of R 4 , R 5 , R 6 and R 7 have the meanings stated above; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity. |