| abstract |
1-(substituted phenylthiocarbamyl) 3,3-disubstituted formamidine compounds having the structural formulan wnereinn n is 1, 2 or 3, R is alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, alkylthio having 1 to 4 carbon atoms, halogen, nitro, acyl having 1 to 4 carbon atoms, hydroxyl andn wherein R 3 and R 4 have the same meaning as R 1 and R 2 defined below, R 1 and R 2 are the same or different and are alkyl having 1 to 6 carbon atoms, or taken together represent the chain -(CH 2 ) P - (X) m - (CH 2 ) q and forming a ring structure with the nitrogen to which they are bound wherein p is 1, 2 or 3, q is 2 or 3, X represents -0-, -S-, -SO-, -SO 2 -, -NR 3 -, R 3 is hydrogen or alkyl having 1 to 6 carbon atoms, and m is 0 or 1 and salts thereof have anti-inflammatory, anti-oedemic and anti-hypertensive activity. n They are prepared by the reaction of the parent thiourea and dialkyl acetal. |