| abstract |
Compounds of the formula: n<CHEM>n whereinn R<1>, which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);n Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;n X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;n andn R, which is attached to carbon atom of ring "B", is a group of the formula: n<CHEM>n where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;n and the pharmaceutically, acceptable salts thereof. n<??>The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates. |