http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0072656-B1

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filingDate 1982-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1986-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1986-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0072656-B1
titleOfInvention Method for the preparation of improved mutant strain of bordetella bronchiseptica and live attenuated vaccine containing it
abstract A new mutant strain of Bordetella bronchiseptica is prepared by applying a mutagen to a strain of B. bronchiseptica to obtain a mutant strain having hereditary markers of at least temperature-sensivity and urease negative (ts- 34.u), and subjecting the resulting phase III organism to repeated culturing on a blood agar medium, each time picking up a cell grown with a comparatively small colony, to obtain a phase I organism which has completely capsular antigen and is hemolytic. This strain has excellent immunogenicity and high safety, and is useful for preparation of a live attenuated vaccine for prophylaxis of B. bronchiseptica infection.
priorityDate 1981-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 22.