http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0072061-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0ef049605214ab2d6cbb74d055c351e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 |
| filingDate | 1982-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40cad410dc0de6ac20732f18c9b1214e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_068e62d4fab05505352b1ba284cb9030 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7135d1f34c4c535159ea6d9b51416505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f1330019053c676eaddbf633939da3d |
| publicationDate | 1983-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0072061-A1 |
| titleOfInvention | Amine derivatives, processes for their production and pharmaceutical compositions containing them |
| abstract | There are described compounds of formula I,n in which D, represents a group of formula II,n where R, and R 5 , or H 3 and R 5 may form a chain -CH 2 CH 2 -, or R 4 and R 5 may form a chain -CH 2 -, or R 3 , R 4 and R 5 are each hydrogen, the remainder of R,, R 3 and R 4 , which may be the same or different, being hydrogen, alkyl or phenyl, n none, one or two of R 6 , R 7 , R 8 and R, represent hydroxy and the remainder represent hydrogen,n X represents a chain -(CH 2 ) n -, optionally substituted by hydroxy, n is an integer from 1 to 7 inclusive, D 2 represents hydrogen, alkyl, phenyl; alkyl substituted by one or more of hydroxy, pyridyl, phenyl; or alkyl substituted by phenyl which in turn is substituted by halogen, alkyl, amino, alkoxy or nitro, or D 2 represents a group of formula III,n where R 2 and R 12 , or R, o and R 12 may form a chain -CH 2- CH 2- , or R 11 and R 12 may form a chain -CH 2 -, or R 10 , R,, and R 12 are each hydrogen, the remainder of R 2 , R 10 and R 11 , which may be the same or different being hydrogen, alkyl or phenyl, none, one or two of R 13 , R 14 , R 15 and R 16 represent hydroxy, and the remainder represent hydrogen, or R 2 and D 2 , together with the nitrogen atom to which they are attached, form a 5 or 6 membered heterocyclic ring, provided that when X is not substituted by hydroxy andn i) when R 3 , R 4 and R 5 are hydrogen, R, and R 2 are both hydrogen or lower alkyl, and two of R 6 , R 7 , R 8 and R 9 are hydroxy, D 2 is not identical to D 1 , or ii) when R,, R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are hydrogen, R 2 and D 2 do not each represent lower alkyl, or do not together with the nitrogen atom to which they are attached, form a 5 or 6 membered heterocyclic ring, or iii) when R,, R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are hydrogen, and R 3 is alkyl, D 2 is not identical to D 1 , or iv) when R, is phenyl, R 3 and R 5 together form the chain -CH 2 CH 2 -, R 6 , R 7 , R 8 and R 9 are hydrogen, n is 1, D 2 and R 2 do not each represent hydrogen or alkyl, or do not together form a heterocyclic ring, nand pharmaceutically acceptable derivatives thereof. n There are also described methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5407956-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5674909-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0117033-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9319036-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5451608-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0188361-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0118974-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105001103-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5023378-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0375668-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0142283-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0117033-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8852556-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9608463-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8402904-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0142283-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MD-1449-G2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9608228-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0375668-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9507885-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9608228-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2192394-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4803225-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4720586-A |
| priorityDate | 1981-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 659.