| abstract |
Pyrrole compounds of the structural formula:n or a pharmaceutically acceptable salt, ester or amide thereof have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation or from direct acidic decarboxylation of a precursor diacid. In the above formula, Ar is phenyl, substituted phenyl, pyridyl, pyrryl, substituted pyrryl, furyl or thienyl; R is, e.g., hydrogen, loweralkyl, lowercycloalkyl, lower(cycloalkyl-alkyl), loweralkenyl or halo-loweralkyl; R' is hydrogen or loweralkyl; R 2 is hydrogen, loweralkyl or halo; R 3 is, e.g., hydroxy, loweralkoxy, substituted loweralkoxy, amino, substituted amino, morpholinyl, glucosamino or heterocyclyl-oxy; X is -(CH 2 ) 0-10 -, -COCH 2 - or -CH 2 CO-; and Y is oxygen, sulfur, sulfinyl, sulfonyl, CH 2 or H with the proviso that when Y is CH 2- , Ar can only be pyrryl, and when Y is H, Ar is pyrryl and R is not present. The compounds are analgesic and anti-inflammatory agents of high activities but low ulcerogenic side effects. |