| abstract |
Antibiotic tylosin derivatives shown by the general formulan wherein R, represents a hydroxyl group; a halogen atom;n [wherein R 5 represents a hydrogen atom or a C, to C 6 alkyl group which may be substituted by a hydroxyl group and R 6 represents a hydrogen atom, a C 1 to C 6 alkyl group which may be substituted by a hydroxyl group, an aryl group, an aralkyl group, a cycloalkyl group having 3-10 carbon atoms, -CO(O) m -R 7 (wherein m represents 0 or 1 and R 7 represents a C 1 to C 6 alkyl group, an aryl group, an aralkyl group, a furanyl group or a pyridyl group), or -CH 2 -R 13 (wherein R 13 represents a mono-, di-, or trifluoromethyl group)]; -N (CH 2 ) n (wherein n represents an integer of 2-15) which may be substituted by an oxo group, a hydroxyl group, a C, to C 6 alkyl group, or a hydroxy C 1 to C 6 alkyl group; an imidazolyl, morpholino, or piperazino group which may each be substituted by a C 1 to C 6 alkyl group; or -OOCCH 2 -R 8 [wherein R 8 representsn (wherein R 9 and R, o may be the same or different and selected from a hydrogen atom and C, to C 6 alkyl groups or which may together form an alkylene group having 3-7 carbon atoms) or -S-R 11 (wherein R 11 represents a furanyl group or a pyridyl group)]: R 2 represents a hydrogen atom or a C, to C 6 alkanoyl group; R 3 represents a methyl or -CH 2 CHO group; R 4 represents a hydrogen atom or a hydroxyl group; A represents O=,n line represents a single bond or a double bond; and and line --- represent a single bond, a double bond, or ; provided that when R, is a hydroxyl group, R 3 is a methyl group and R 4 is a hydrogen atom, or said line - is ; and that when R, is a halogen atom, R 3 is a methyl group or said line - is . |