| abstract |
Compounds of formula (I):n and salts and in vivo hydrolysable acyl derivatives thereof, whereinn R 1 is hydrogen or methyl; R 2 is hydrogen or methyl; R 3 is phenyl unsubstituted or substituted with one or two of the following:- fluorine, chlorine, bromine, trifluoromethyl, C 1-6 straight or branched chain alkyl or C 1-6 straight or branched chain alkoxy; or is benzofuran-2-yl; R 5 is a hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; R 4 is moietyn wherein X is C 2-10 alkylene which may be straight or branched provided that the oxygen and nitrogen are separated by at least two carbon atoms, A is hydrogen; C 1-6 straight or branched alkyl or benzyl optionally substituted with halogen, lower alkyl or lower alkoxy. R 6 is hydrogen; C 1-6 straight or branched alkyl; C 1-6 straight or branched alkylsulphonyln R 7 is C 1-6 straight or branched alkyl; C 1-6 straight or branched alkoxy; amino, mono- or di- (C 1-6 straight or branched alkyl) amino; orn is a 5,6 or 7 membered cyclic amine optionally containing a second hetero atom selected from oxygen, nitrogen and sulphur, and n is 1 or 2 have anti-obesity and anti-hyperglycaemic activity. |