| abstract |
A compound of formula (III):n pharmaceutically acceptable salt, ester amide or bioprecursors thereof,n wherein R' is optionally substituted aryl, aralkyl, aromatic heterocyclic or aromatic heterocyclylalkyl group, and Z is a naphthyl group, optionally substituted with one or more groups selected from C 1-6 alkyl, halogen, hydroxy or trifluoromethyl, or Z is a 5 or 6 membered heterocyclic group containing one or more nitrogen, oxygen or sulphur atoms, with at least one of the hetero- atoms being attached to the same carbon atom as the methylene group, and optionally substituted with C 1-5 alkyl, halogen, hydroxy or trifluoromethyl, with the proviso that when R 1 is benzyl and Z is a naphthyl group, the compound of formula (III) is not in the DL-form. |