| abstract |
Novel aniline derivatives represented by the general formula (1): n<CHEM>n [wherein, subject to certain provisos R<0>, R<1> and R<2> are hydrogen, halogen, nitro, amino, carboxy, cyano, hydroxy, sulphonamido, lower alkyl, lower alkoxycarbonyl, lower alkoxy, lower alkanoyl, lower alkylamino, lower alkylthio, lower alkanoylamino or a group n<CHEM>n (wherein R<5> and R<6> are hydrogen, lower alkyl or cycloalkyl or form a heterocyclic group with the adjacent nitrogen atom); R<3> is cyano, nitro, halogen, lower alkyl or a lower alkoxy; m is an integer of 1 to 3; R<4> is hydrogen or lower alkyl; and A is lower alkylene] and their salts act directly on the heart, and have myocardial contraction activity (positive inotropic activity) and coronary blood flow increasing activity, and are thus useful as cardiotonics. |