| abstract |
Compounds of the formulan wherein R and R' are each independently hydrogen and lower alkyl R 2 is hydrogen or hydroxyl, m is an integer of 0 or 1, n is an integer of 0 or 1, and when m is 1, n is 0; when m is 0, n is 1, and X and Y are each independently hydrogen, halogen, alkoxy of 1 or 2 carbon atoms, lower alkyl, hydroxy and trifluoromethyl, and the stereoisomers thereof. n They are prepared by reacting a 2-bromodiaryl methane with a 4-aminocyclohexanone, optionally dehydrating the resulting cyclohexanol and optionally hydro- . genating the thus obtained cyclohexene; or by reacting 2-bromodiaryl methane with 1,4-dioxaspiro (4.5)decan-8- one, transforming this to the 4-oxo-cyclohexanol derivative, reacting this with hydroxyl amine to the corresponding oxime and finally reducing this. These compounds are useful as antidepressants and anticonvulsants. |