| abstract |
Process for the production of IFN-y comprising incubating for a period of time at least sufficient for the production of IFN-y, a viable cell suspension which includes (a) leukocytes, (b) an inducer for production of IFN-y, and (c) a modulator for said inducer selected from the group consisting of mezerein and 12, 13-phorbol butyrate, said inducer and said modulator being present in said suspension in amounts sufficient to stimulate production of IFN-y; process for producing homogeneous IFN-y; process for producing IFN-γ mRNA; and cloning process for production of IFN- . Products disclosed are homogeneous IFN-γ and its 2 species; and the host calls containing the recombinant cloning vehicle containing ONA segment coding for IFN-y. |