| abstract |
Tricyclic pyrroles of formula I. wherein R 1 H or C 1 -C 4 alkyl, H 2 H or -CO-C n H 2n -R 3 , R 3 halogen or -N (R 4 ) R 5 , R 4 H, C 1 -C 4 alkyl or C 3 -C 5 alkenyl, R 5 C 1 -C 4 alkyl, optionally substituted by di (C 1 -C 4 alkyl) amino, or C 3 -C 5 alkenyl, or R 4 and RS together pyrrolidino, piperidino, morpholino , Perhydroazepino, piperazino, 4- (methyl, ethyl or benzyl) -1-piperazinyl, homopiperazino or 4-methyl-1-homopiperazinyl, R 6 , R 7 and R 8 H or C 1 -C 4 alkyl and n 1 or 2 mean, and their acid addition salts with inorganic and organic acids are new compounds with antiulcerogenic properties or new intermediates for the preparation of such compounds. Methods for making these compounds are given. |