| abstract |
4(3H)-quinazolinones of formulan whereinn R 1 and R 3 , independently from each other, represent a lower alkyl group; R 2 represents a lower alkoxycarbonyl group; Q represents a phenyl group or a substituted phenyl group R 4 represents a hydrogen atom or a lower alkyl group; R 5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy-(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower) alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower) alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)-alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups. Z, and Z 2 , independently from each other, represent an oxygen or sulfur atom; and an acid addition salts thereof, are useful as hypotensive agents. There is also disclosed a process for the production of these derivatives and pharmaceutical compositions comprising said compounds. |