| abstract |
5-Cyan-prostacyclin derivatives of the general formula I <IMAGE> in which R1 is the radical OR2, where R2 can be hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic radical, or the radical NHR3 with R3 in the meaning of an acid radical or a hydrogen atom or Alkyl, cycloalkyl or heterocyclic radicals as defined for R2, B is a straight-chain or branched-chain alkylene group with 2-10 C atoms, W is a free or functionally modified hydroxymethylene group or a free or functionally modified <IMAGE> R <4> is a free or functional modified hydroxy group, R5, R6, R7, R8 is a hydrogen atom or an alkyl group with 1-5 C atoms or a methoxy group, R9 is an alkyl group with 1-5 C atoms and, if R2 has the meaning of a hydrogen atom, its salts with physiologically compatible bases mean and a process for their preparation. The new prostacyclins work among other things hypotensive. |