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filingDate 1981-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1982-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0050831-A2
titleOfInvention Production of protein with reduced nucleic acid
abstract Microorganisms with low nucleic acid content are produced by acid treating of the microorganism. One embodiment relates to the extraction of so treated microorganisms after their separation from the acid treating fluid, using a strong base for the extraction. Another embodiment relates to the neutralization of the acid treating fluid containing nucleic acids prior to the introduction of this fluid into the fermentation zone, the anion of the acid and the metal cation used in the neutralization step forming minerals desirable for the growth medium in the fermentation step.
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