| abstract |
Novel fluorinated diaminobutane derivatives are inhibitors of gamma-aminobutyric acid transaminase and have the following general Formula l:-n n R 1 represents hydrogen, C 1- C 6 alkyl or phenyl-C 1 -C 4 R, represents hydrogen, C 1 -C 6 alkyl or phenyl-C 1 -C 4 alkyl; R2 represents hydrogen, C 1- C 6 alkyl, phenyl-C 1 -C 4 alkyl, or R 4 is as defined below; R 3 represents hydrogen or, except when R 2 represents R 4 , R 4 , where R 4 is as defined below; each R 4 independently represents C 2 -C S alkylcarbonyl, phenylcarbonyl, phenyl-(C,-C 4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from the carboxy moiety of an L-aminocarboxylic acid; and p represents 1 or 2, and pharmaceutically acceptable acid addition salts thereof. |