| abstract |
Dimeric indole-dihydroindole compounds of the formulan whereinn R is OCH 3 , NH 2 , NHCH 3 , NHC 2 H 5 , NHC 2 H 4 OH or NH-NH 2 ; R 1 is OH or acetoxy; R 2 is CH 3 or CHO; andn wherein R 5 is H, methyl, n NHCOO methyl or methylthiomethyl; and their pharmaceutically-acceptable acid addition salts, active as anti-tumor agents in mammals, are prepared from their C-4' hydroxy analogues by reaction with hydrogen cyanide or nitriles under strongly acidic conditions. |