| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 |
| filingDate |
1981-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b8c810e65eebd9add7e149cfc7eff20 |
| publicationDate |
1982-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0044134-A2 |
| titleOfInvention |
Composition for reducing intraocular pressure |
| abstract |
Method and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a carbonic anhydrase inhinitor comprising a sulfonamide having the following properties:n a. sufficiently soluble in water to form a 1-5%, by weight, solution or a pKa of not greater than 7.0; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3×10 -8 molar; e. first order rate constant for penetration of the sulfonamide through a isolated rabbit cornea of at least 0.002 hr.-'; f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3411104-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0419311-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6228786-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010128872-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2155331-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0419311-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2560769-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0009106-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0009106-A3 |
| priorityDate |
1980-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |