| abstract |
2,2-dimethyl-penam-3-carboxylic acid-1,1-dioxide compounds of the formula <IMAGE> in which R1 is hydroxy or etherified or esterified hydroxy and R2 is carboxyl or protected carboxyl, and salts of such compounds which are salt-forming Have group, have β-lactamase inhibiting properties. Pharmaceutical preparations containing these compounds, optionally in combination with β-lactam antibiotics, are particularly suitable for combating infections which are caused by microorganisms which produce β-lactamase. Process for the preparation of compounds of formula (I) and intermediates. |