| abstract |
N-substituted aporphines of the formulan wherein R, is lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl, R 2 is hydrogen orn wherein R 3 is lower alkyl and R 4 is hydrogen or R 2 0 and the acid addition salts thereof with the proviso that when R 4 is hydrogen R 1 is 2-chloroethyl. Representative compounds of this invention are potent emetics and dopamine antagonists. |