| abstract |
Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via central intermediates II and III:n n n wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R 6 , R 7 and R 8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R 1' and R e are hydrogen, or a readily removable protecting group; R a , R b and R c are selected from alkyl, aryl or aralkyl. |