| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
1981-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_551c00180177cdc5a1f683a8837242a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f5c4932ebc2ab136d0feb5c27d930c8 |
| publicationDate |
1981-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0036762-A2 |
| titleOfInvention |
A pharmaceutical formulation of a vinca dimer |
| abstract |
A pharmaceutical formulation which comprises as an active ingredient (VLB or 4-desacetyl VLB) 3-(2-chloroethyl) carboxamide or a pharmaceutically-acceptable acid-addition salt thereof with a pharmaceutically-acceptable carrier therefor. Process for preparing the active ingredient include hydrolyzing the corresponding spirooxozolidinidione, reacting the carboxazide with 2-chloroethylamine, and reacting the 3-(2-hydroxyethyl)-carboxamide with a reagent which facilitates the replacement of a hydroxy function with chlorine and source of chlorine, and optionally, desacetylating; optionally, acetylating; and optimally salifying. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9631518-A1 |
| priorityDate |
1980-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |