Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef1a63d62269b5b64f99ee8720351481 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0613 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-125 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-075 |
filingDate |
1981-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_397570ff4e129b749dc91c487887e830 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b3274b223e619a1bd96e014752a066b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_915f5b4e3f9d0a97c328bbd82cf0a4f5 |
publicationDate |
1981-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0036258-A2 |
titleOfInvention |
Process for producing aspartame |
abstract |
The artificial sweetener aspartame, a dipeptide with the formula Asp-Phe-me, is produced using a cloned microorganism. A DNA which codes for a large stable peptide comprised of the repeating amino acid sequence (Asp-Phe)n is inserted into a cloning vehicle which in turn is introduced into a suitable host microorganism. The host microorganism is cultured and the large peptide containing the repeating Asp-Phe sequence is harvested therefrom. The free carboxyl group of the large peptide is benzylated and then hydrolysed to benzyl Asp-Phe dipeptides. This dipeptide is methylated and then debenzylated to form aspartame. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2479259-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9632468-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9632468-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2153363-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0139501-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6204008-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014010755-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8805082-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8500621-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9428783-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0139501-A2 |
priorityDate |
1980-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |