abstract |
A process for preparing a N-alkylamine or N, N-dialkylamine, which comprises reacting a primary or secondary amine with a primary or secondary alcohol in the presence of a catalyst selected from iridium, rhodium, ruthenium, osmium, platinum, palladium and rhenium, present either as the metal or a salt or complex thereof. The catalyst is preferably a complex such as RhH(PPh 3 ) 4 . The process can be used to cause cyclisation, including internal cyclisation so that, by way of example, N-methyl-pyrrolidine may be prepared from (1) pyrrolidine and methanol; (2) 1,4-butanediol and methylamine; and (3) 4-methylamino-1-butanol. |