| abstract |
Compounds of formula (1):- n<CHEM>n and pharmaceutically acceptable salts thereof are disclosed with a process for their preparation. n<??>In formula (I) A is a covalent bond, an alkylene chain -(CH2)n- in which n is a positive integer 2,3,4 or 6, a branched alkylene chain of from 2 to 4 carbon atoms, or phenylmethylene; R1 is hydrogen, 3- or 4-bromo, 3- or 4-chloro or 3- or 4-trifluoromethyl; andn R2 is hydrogen, with the proviso that when n is 2, R1 is 4-chloro, 4-bromo, 4-methoxy or 3-trifluoromethyl and R2 is hydrogen or together with R1 in adjacent positions forms either a 3,4-dichloro substitution or a fused benzo ring, and further with the proviso that when A is a covalent bond R1 is not hydrogen or 4-chloro. n<??>The compounds of the invention are SRS-A antagonists. |