http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0033341-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4dae7331034b6b26116b7c2f7acb115 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10 |
| filingDate | 1981-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9564346488023207859b83d5d3e21aa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_303c8840dad565c1eed1a3d84a0a0d49 |
| publicationDate | 1981-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0033341-A1 |
| titleOfInvention | Cytotoxic nucleoside-corticosteroid phosphodiesters |
| abstract | Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form phosphodiester-like products of cytotoxic nucleoside-corticosteroids of the formula: steroid-OPO-sugar-heterocycle (FORMULA) or the steroid is the residue formed by extraction of a hydroxylated hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene ring which is esterified to half the phosphate at position 21; the sugar is a naturally occurring pentose or deoxypentose in the form of furanose, preferably ribose, deoxyribose, lyxose, xylose or arabinose and especially ribose, deoxyribose or arabinose, which is esterified to the phosphate half at the (5 ') position and covalently links to half of the etherocycle at position (1 ') to form a nucleoside; and the heterocycle is a purine, pyrimidine, hydrogenated pyrimidine, triazolopurine or similar nucleoside base. The conjugates have a better therapeutic index compared to the nucleoside or base compounds of the same family, and therefore are useful as cytotoxic, antiviral and antineoplast agents. |
| priorityDate | 1979-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 892.