| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-58 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-58 |
| filingDate |
1980-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e6bd04647cd3822377d07de5f062537
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b13f5e64008bcd60581e0ffadabab2e |
| publicationDate |
1981-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0032620-A1 |
| titleOfInvention |
Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters |
| abstract |
2-(4-Nitrophenyl)-2-methylmalonate esters are prepared by reacting 4-nitrophenyl halides with methylmalonate esters in the presence of a base. The base is preferably an alkali metal hydroxide or potassium carbonate. The products can be reduced to the corresponding 2-(4-aminophenyl)-2-methylmalonate esters. The 3-fluoro-4-nitrophenyl and 4-amino-3-fluorophenyl deriviatives of both types of esters are novel. n The aminophenylmalonate esters may be coupled with a benzene compound and decarboxylated to give 2-arylpropionic acids such as flurbiprofen. Alternatively, decarboxylation of the 4-nitrophenylmalonate ester may be followed by reduction and coupling, again to give 2-arylpropionic acids and esters. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7342040-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4766148-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0103265-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0809631-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0809631-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0103265-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4542233-A |
| priorityDate |
1979-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |