| abstract |
wherein R is H or OH and; when R 1 is H, R 2 is H and R 3 and R 4 are both H or both OH, and n when R 1 is OH, R 2 is H, R 3 is OH or C 1 -C 6 alkyloxy and R 4 is OH, or R 2 isn and R 3 and R 4 are both OH, and the acid addition salts thereof. n n n Cyclic peptide nuclei for formula 1 are prepared by the enzymatic deacylation of an appropriate antibiotic using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. NRRL 12052. The cyclic peptide nuclei and the salts thereof are useful intermediates in the preparation of new semi-synthetic antifungal agents. |